丁香园呼吸氢气可治疗心肌缺血
在啮齿动物实验中,吸入氢气已经被证实可以通过减轻缺血再灌注损伤而限制脑和肝的梗塞体积。当转化为临床实践时,由于血管成形术再通血管已经是常用治疗手段,这种吸入氢气限制梗塞面积的疗法将被应用于急性心肌梗死患者的治疗。
因此,我们通过鼠来研究是否吸入氢气减轻缺血再灌注损伤来起到心脏保护作用。在离体灌注的心脏,氢气可以改善缺氧复氧后左室收缩功能的恢复,在梗死相关动脉的冠脉血流重建前,吸入的氢气可以迅速输送并到达处于危险的缺血心肌,缺血及再灌注期间吸入在不燃水平的氢气可以缩小梗死面积,不改变血流动力学参数,来预防心室的有害重构。所以,在冠脉血运重建时,氢气吸入将成为一种减轻缺血再灌注损伤的非常有希望的措施。(来源:丁香园科技动态论坛)
附原文:InhalationofHydrogenGasReducesInfarctSizeintheRatModelofMyocardial3Ischemia–ReperfusionInjury
Inhalationofhydrogen(H2)gashasbeendemonstratedtolimittheinfarctvolumeofbrainandliverbyreducingischemia–reperfusioninjuryinrodents.Whentranslatedintoclinicalpractice,thistherapymustbemostfrequentlyappliedinthetreatmentofpatientswithacutemyocardialinfarction,sinceangioplasticrecanalizationofinfarct-relatedoccludedcoronaryarteryisroutinelyperformed.Therefore,weinvestigatewhetherH2gasconferscardioprotectionagainstischemia–reperfusioninjuryinrats.Inisolatedperfusedhearts,H2gasenhancestherecoveryofleftventricularfunctionfollowinganoxiareoxygenation.InhaledH2gasisrapidlytransportedandcanreach‘atrisk’ischemicmyocardiumbeforecoronarybloodflowoftheoccludedinfarct-relatedarteryisreestablished.InhalationofH2gasatin治白瘕风哪家医院有名北京最有效白癜风的治疗方法
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