胰岛素不能恢复七氟醚后处理对糖尿病大鼠的

BenjaminDrenger,M.D..et.al,DiabetesBlockadeofSevofluranePostconditioningIsNotRestoredbyInsulinintheRatHeart.Anesthesiology,,（6）：–72.

Abstract

Background:Thepossibilityofrestoringsevofluranepost-conditioning(sevo-postC)cardioprotectionindiabeticanimalsisuncertain.Wehypothesizedthatattenuationofmyocardialinjurybysevo-postCmightbehinderedbyinhibitionofsignaltransducerandactivatoroftranscription(STAT)3–regulatedactivityofphosphatidylinositol3-kinase(PI3K)indiabeticanimals.TodeterminewhetherpostCcardioprotectioncanberestoredbynormoglycemia,wetreatedratswithinsulin.

Methods:Diabeticornondiabeticratswererandomlysubjectedto30-minischemia/reperfusion,withischemicpostCorsevo-postC,withandwithoutmitochondrialadenosinetriphosphate–dependentpotassiumchannelblocker5-hydroxydecanoatesodiumandPI3Kantagonistwortmannin.Theinfarctarea,phosphorylatedSTAT3,andapoptosiswereexamined.Studieswererepeatedafterinsulintreatment.

Results:IschemicpostCandsevo-postCsignificantlyreducedinfarctsizeby50%inthenondiabeticrats(P0.),aphenomenon







































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