体外循环下心肌的损伤及相应的保护措施

DeHert,S.andA.Moerman,Myocardialinjuryandprotectionrelatedtocardiopulmonarybypass.BestPracticeResearchClinicalAnaesthesiology,.29(2):p.-.

原文摘要：

Duringcardiacsurgerywithcardiopulmonarybypass,theheartisisolatedfromthecirculation.Thisinevitablyinducesmyocardialischemia.Inadditiontothisischemicinsult,anadditionalhitwilloccuruponreperfusion,whichmayworsentheextentoftissuedamageandorgandysfunction.Overtheyears,severalstrategieshavebeendevelopedthataimtoattenuateand/ormodulatetheextentofthisischemiaereperfusioninjuryrelatedtotheepisodeofcardiopulmonarybypass.Thisarticlereviewsthepathophysiologyofmyocardialinjuryrelatedtocardiopulmonarybypassandsummarizespotentialtherapeuticstrategiesthatmaymodulatetheextentofthismyocardialinjury.

摘要翻译：

由于体外循环下的心脏手术阻断了心脏的血液灌注，不可避免的造成心肌的缺血。而除了缺血诱发的心肌损伤外，再灌注引发的心肌损伤进一步加重心肌组织损伤和器官功能障碍。多年来，几种心肌保护策略已经成功的用于改善和/或调节体外循环期间心肌缺血再灌注损伤的程度。本篇文章综述了体外循环下心肌损伤的病理生理改变以及可能改善心肌损伤程度的治疗措施。

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